1. Angelo Debono (Press for Ancestry), married 1551 to Agata (a former slave), with issue.

1.1. Mro Matteo Debono, married (1) 1587 Attard to Imperia Cafor, married (2) 1612 Attard to Grazia Attard, with issue.

1.1.1. (Second Marriage) Giacomo Debono, married 1647 Siggiewi to Maria Zammit, with issue.

1.1.1.1. Domenico Debono, married to 1677 Qormi to Caterina Mamo, with issue.
1.1.1.1.1. Domenico Debono, married (1) 1714 Mdina Malta to Camilla Busuttil,  married (2) 1735 Mdina Malta to Maddalena Azzopardi, with issue.

1.1.1.1.1.1. (First Marriage) Paolo Debono., married 1754 Mdina Malta to Anna Mizzi., with issue.
1.1.1.1.1.1.1.  Sir Giuseppe Calcedonio Debono, G.C.M.G. (1756-1837), married (1) 1778 to Eugenia Agius, married (2) 1801 Valletta to Cajetana Borg, with issue.
1.1.1.1.1.1.1.1. (First Marriage) Dr Massimilano Debono LLD., married Carmela Rocco-Peralta, with issue.
1.1.1.1.1.1.1.1.1. Teresia Debono, married Judge Prof. Edgar Ganado, LLD., with issue
1.1.1.1.1.1.1.2. Maria Teresa Debono, married 1802 Mdina Malta to  with issue
1.1.1.1.1.1.1.2.1. SAINT Fra. Nazju Falzon, (1813-65), dunm.
1.1.1.1.1.1.1.2.2. Father Kalcidon Falzon, Treasurer of the Cathedral Chapter
1.1.1.1.1.1.1.2.3. Father Francis Falzon, (1807-95)
1.1.1.1.1.1.1.2.4. Dr. Anthony Falzon LL.D married with issue
1.1.1.1.1.1.1.3. Don. Emmanuele Debono, dunm.
1.1.1.1.1.1.1.4. Don. Dr. Antonio Debono LLD., dunm.
1.1.1.1.1.1.1.5. Annunicata Debono.
1.1.1.1.1.1.1.6. Angelica Debono.
1.1.1.1.1.1.1.7. Marco Lugi Debono.
1.1.1.1.1.1.1.8. Vincenzo Debono.
1.1.1.1.1.1.1.9. Bartolomeo Debono.

1.1.1.1.1.1.1.10. (Second Marriage) Judge Dr Antonio Maria Debono JUD., married 1818 to Anna Maria Grungo., with issue.

1.1.1.1.1.1.1.11. Vincenza Debono, (1806-1901).

1.1.1.1.1.2. Maria Debono, married 1737 to Arrigo Valenza of d’Agosta Sicily., with issue.

1.1.1.1.1.3. Antonia Debono, married 1743 Mdina Malta to Michele Preca., with issue.

1.1.1.1.1.4. Giuseppe Debono, married (1) 1741 Mdina to Giovanna Callus, married (2) 1770 Kirkop to Anna Farrugia, with issue.

1.1.1.1.1.4.1. Pietro Debono, married 1767 Mdina to Maria Callus.

1.1.1.1.1.4. Saverio Debono, married  (1) 1746 Mdina Malta to Vittoria Azzopardi, married (2) 1776 Ghargur to Grazia Decelis

1.1.1.1.2. Laura Debono, married 1734 Mdina to Giuseppe Mamo.

1.1.1.1.3. Baldassare Debono, married (1) 1695 Zebbug to Clara Vassallo (d/o Tomaso and Domenica), married (2) 1720 Curmi to Giacobina Dimech.

1.1.1.2. Giuseppe Debono, married 1676 Zebbug to Maruzza Gatt.

1.1.1.3. Gio Maria Debono, married 1677 Curmi to Caterina Cumbo (d/o Alfonso and Maria).

1.1.1.4. Paolo Debono, married 1683 Curmi to Anna Zammit.

1.1.2. (Second Marriage) Vittorio Debono, married 1628 Curmi to Caterina Delia.

1.1.3. Marino Debono, married 1632 Curmi to Maria Mallia.

1.1.4. Bartolo Debono, married 1628 Zebbug Malta to Enziona Felici.

1.1.5. Francesco Debono, married 1659 Mdina to Grazia Fenech.

1.2. Domenico Debono, married 1587 Attard to Domenica Mangion.

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Corrections and updating.