1. Giuseppe Sant, married to Caterina Calafato, with issue.

1.1. Ignazio Sant, married 1795 Birkirkara to Teresa Cauchi, with issue.

1.1.1. Giacomo Sant, married 1827 Balzan to Maria Dingli, with issue.

1.1.1.1. Carmelo Sant, married 1865 Birkirkara to Filomena Muscat, with issue.

1.1.1.1.1. Giacomo Sant, married 1887 Birkirkara to Antonia Fenech, with issue.

1.1.1.1.1.1. Carmelo Sant, married 1913 Msida to Carmela Bonello, with issue.

1.1.1.1.1.1.1. Giuseppe Sant, married 1947 Birkirkara to Josephine Mizzi, with issue.

1.1.1.1.1.1.1.1.  Dr Alfred Sant, M.Sc., M.B.A., D.B.A. (HARVARD), Prime Minister of Malta (r.1996 - 1998), (1948-., married to Mary Darmanin,  with issue.

1.1.1.1.1.1.1.1.1. Marta Sant, B.Psych (Hons).

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