1. Alfonso Despasquale, married to Maria N, with issue.

1.1. Giuseppe Despasquale, married 1767 Senglea to Teresa Inglott, with issue.

1.1.1. Agostino Despasquale, married 1795 Senglea to Teresa Bellia, with issue.

1.1.1.1. Giuseppe Giorgio Despaquale, married 1826 Qormi to Giacoma Grech, with issue.

1.1.1.1.1. Agostino Giuseppe Despasquale, married 1868 Qormi to Vincenza Vassallo, with issue.

1.1.1.1.1.1. Annetto Despasquale, married 1904 Qormi to Maria Dolores Azzopardi, with issue.

1.1.1.1.1.1.1. Edgar Vincenzo Despasquale, married 1937 Floriana to Grace Coleiro, with issue.

1.1.1.1.1.1.1.1.  Mons. Annetto Despasquale BA, LicD, JCD, Prel.SS, Auxiliary Archbishop of Malta, (r. 1998- Present)

1.1.1.1.1.1.1.2. Judge Anton Despasquale, (1942-., married Carmen Camilleri., with issue.

1.1.1.1.1.1.1.2.1. Edgar Despasquale.

1.1.1.1.1.1.1.2.2. Isabel Despasquale.

1.1.1.1.1.1.1.2.3. Maria Despasquale.

1.1.1.1.1.1.1.3. Godfrey Despaquale, married to Cecilia NN, with issue.

1.1.1.1.1.1.1.3.1. Dr Lennart Despasquale LLD, married 1996 to Suzannah Leone-Ganado BA., with issue.

1.1.1.1.1.1.1.3.1.1. Federica Despasquale.

1.1.1.1.1.1.1.3.1.2. Siena Despasquale.

1.1.2. Giovanni Despasquale, married 1801 Senglea to Maria Farrugia.

1.2. Antonio Despasquale, married to Giuseppa Pulleda, with issue.

1.2.1. Vincenzo Despasquale, married 1807 Senglea to Clara Santa Cacapoddo.

Unconnected at this stage.

1. Notary Baldassare Despasquale, married to Maddalena N, with issue.

1.1. Antonia Despasquale, married 1752 Valletta to Gio Andrea Palmier.

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Corrections and updating.