1. Francesco di Pasquale, married to Imperia N, with issue.

1.1. Giacomo di Pasquale, married (1) 1667 Valletta to Maria Martin, married (2) 1673 Borgo to Teresa Sammut, married (3) 1682 Valletta to Clara Muscat, with issue.

1.1.1. (Second Marriage) Giuseppe di Pasquale, married 1700 Valletta to Maddalena Pagies, with issue.

1.1.1.1. Giovanni Andrea Alfonso di Pasquale, married (1) 1727 Borgo to Theresa Fenech, married (2) 1730 Borgo to Maria Fino, with issue.

1.1.1.1.1. (Second Marriage) Giuseppe di Pasquale, married 1767 Senglea to Teresa Inglott, with issue.

1.1.1.1.1.1. Agostino de Pasquale, married 1795 Senglea to Teresa Bellia, with issue.

1.1.1.1.1.1.1. Giuseppe Giorgio de Pasquale, married 1826 Qormi to Giacoma Grech, with issue.

1.1.1.1.1.1.1.1. Agostino Giuseppe de Pasquale, married 1868 Qormi to Vincenza Vassallo, with issue.

1.1.1.1.1.1.1.1.1. Annetto de Pasquale, married 1904 Qormi to Maria Dolores Azzopardi, with issue.

1.1.1.1.1.1.1.1.1.1. Edgar Vincenzo Depasquale, married 1937 Floriana to Grace Coleiro, with issue.

1.1.1.1.1.1.1.1.1.1.1.  Mons . Annetto Depasquale BA, LicD, JCD, Prel.SS, Auxiliary Archbishop of Malta , ( 1938 - 2011), (r. 1998-2011).

1.1.1.1.1.1.1.1.1.1.2. Judge Anton Depasquale, (1942-., married Carmen Camilleri., with issue.

1.1.1.1.1.1.1.1.1.1.2.1. Edgar Depasquale.

1.1.1.1.1.1.1.1.1.1.2.2. Isabel Depasquale.

1.1.1.1.1.1.1.1.1.1.2.3. Maria Depasquale.

1.1.1.1.1.1.1.1.1.1.3. Godfrey Depaquale, married to Cecilia NN, with issue.

1.1.1.1.1.1.1.1.1.1.3.1. Dr Lennart Depasquale LLD, married 1996 to Suzannah Leone-Ganado BA., with issue.

1.1.1.1.1.1.1.1.1.1.3.1.1. Federica Depasquale.

1.1.1.1.1.1.1.1.1.1.3.1.2. Siena Depasquale.

1.1.1.1.1.2. Giovanni de Pasquale, married 1801 Senglea to Maria Farrugia.

1.1.1.1.1.3. Carolo de Pasquale, married 1808 Borgo to Maria Anna Canzuh.

1.1.1.1.1.4. Maria de Pasquale, married 1794 Valletta to Pasquale Farrugia, with issue.

1.1.1.1.1.4.1. Giuseppe Farrugia, married 1816 Valletta to Polixemia Rigo.

1.1.1.1.2. Antonio di Pasquale, married to Giuseppa Pulleda, with issue.

1.1.1.1.2.1. Vincenzo di Pasquale, married 1807 Senglea to Clara Santa Cacapoddo.

1.1.1.2. Teresa di Pasquale, married 1728 Borgo to Michele Zahra, with issue.

1.1.1.2.1. Luca Zahra, married 1753 Borgo to Caterina Seichel, with issue.

1.1.1.2.1.1. Maria Anna Zahra, married 1790 Valletta to Giuseppe Fallanca, with issue.

1.1.1.2.1.1.1. Vincenza Fallanca, married 1807 to Marquis Lorenzo Testaferrata.

1.1.2. (Third Marriage) Notary Baldassare di Pasquale, married to Maddalena Ramozetta, with issue.

1.2. Onorato di Pasquale, married 1655 Valletta to Caterina Imbert.

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